Monday, 5 April 2010

An Expert on Choice Chooses

By PENELOPE GREEN
New York Times
March 17, 2010

SHEENA IYENGAR, the S. T. Lee professor of business at Columbia University, was home from work the other day, dressed in a cream-colored twin set and a sparkly gold pencil skirt. She was seated at the head of a long cherry dining table she designed with her husband, Garud Iyengar, a financial engineer who is also a professor at Columbia, in the living room the two had decorated in earthy colors with a mix of furniture found at auction, in India and at a store in downtown Manhattan.


There was a clear point of view — a consistent style or discernible taste, if you will — that linked all the objects in the room, including Dr. Iyengar’s outfit. Yet there was a mystery, too: how had Dr. Iyengar, a social psychologist who firmly believes that taste is an unreliable compass, and who is also blind, navigated the murky landscape of self-expression and made a series of decisions in all sorts of categories — clothes, paint, furniture — that would seem to require both sight and a conviction about taste?

Like most of us, Dr. Iyengar is an expert in none of these areas. She is, however, an expert in choice, after a decade and a half of research teasing out the patterns of human decision-making and revealing its contradictions: how we love choice but are confounded, even paralyzed, by too much of it.

In “The Art of Choosing,” her first book, out this month, she presents the biology and the psychology of choice, examining how different cultures construct choice and pondering how we might choose better. “We’re born with the desire, but we don’t really know how to choose,” she said. “We don’t know what our taste is, and we don’t know what we are seeing. I’m a great believer in the idea of not choosing based on our taste. I could wear makeup today, and one person would say it looks bland, another would say it looks fake, and another might tell me I look really natural. Everyone is convinced their opinion is the truth, and that’s what I struggle against. But doesn’t everyone? What I do is aim for consensus. That’s my rule of how to choose.”


Dr. Iyengar wasn’t kidding. She has built a wardrobe and furnished her sprawling Upper West Side apartment in a postwar building owned by Columbia University by convening a committee of experts, trusted advisers that include her teaching assistants, her friends and her husband, whose opinions she gathers and then weighs, one against the other. It’s an elaborate and fascinating process she follows out of necessity and offers as a tool for the rest of us.


“You cannot get to the heart of how things are going to be perceived unless you ask these judges,” she said. “When you’re choosing furniture for your home that’s supposed to express who you are, what you are also saying is you want other people to infer what you want them to infer. What if they see something different? Wouldn’t it be really depressing if you’re trying to be bohemian and instead they see you as Rush Limbaugh?”

Animals, particularly humans, love choice, and seem to thrive on it. Like Robert Frost, rats will choose mazes with branching paths, even though there is no reward for doing so. Four-month-old humans, in one experiment that allowed them to “choose” pleasant music by tugging on strings, were palpably irritated when their strings were taken away, even though the same music played at random intervals. Even on a cellular level, brain imaging, mapping a biology of choice, reveals that neurons respond more to rewards people have chosen than those they have passively received.

Study after study concludes that it’s the choosing that delights, more than the object of choice. Here’s the paradox: too much choice paralyzes us, no surprise to anyone who has ever stumbled into a Super Stop & Shop and tried to buy eggs. Dr. Iyengar is the author of a now-famous academic study that describes this paralysis.

In the mid-’90s, when she was a doctoral student at Stanford, Dr. Iyengar, now 40, conducted her jam study, in which research assistants set out pots of jam on tables in a supermarket — different flavors in groups of 6 and 24 — and offered samples to shoppers. What she discovered was that many of the shoppers who visited the table with the smaller sampling ended up buying jam along with their other groceries, as compared with a mingy few among those who visited the table with the greater selection.

The study — more is less! — made Dr. Iyengar a darling of corporate America and a celebrity in social science circles. In her book, she described the magic number — seven — at which “more” turns into less, inspired by a 1956 study that showed that our senses can easily discern anywhere from five to nine objects of perception, like sounds, colors or lights — any more, and we begin to make errors.

The number of people in Dr. Iyengar’s committee of experts hovers around five, she said. There are three research assistants: Esther Adzhiashvili, who is Russian and loves color; Kate McPike, who hails from Delaware and “likes J. Crew”; and John Remarek, “who everyone says you can tell has no interest in clothes.”

Sometimes her personal trainer will be roped in, or another friend. Her husband always gets a vote (she sees him as “maverick” in his tastes — he wanted to paint their family room black — yet he described himself in an e-mail message to this reporter as conservative, proving his wife’s contention that labels are wildly subjective).

The Drs. Iyengar met by chance, at a bus stop in San Francisco when they were graduate students at Stanford. She found him morose and geeky; he thought she was confident, bright and funny. Predictably, they fell in love, and married a few years later, horrifying their families — he is Hindu, she was raised a Sikh — whose respective cultures view arranged marriages as sacrosanct. (Panicked, his mother visited the family astrologer who told her not to fret; the couple had been married in seven past lives and would be married in seven future ones as well.) It was an involved process, Dr. Garud Iyengar told this reporter later via e-mail, to choose someone outside his caste and his religion. In the end, his marriage calculus was solved by the tricky factor of love.

“Over time,” he said, “she became someone I could not live without.” Explaining romantic attraction, Dr. Sheena Iyengar writes, is nearly impossible. In her book, she relates the experience of one of her graduate students who traveled to India with a woman in whom he had a romantic interest.

He knew of the “love on a suspension bridge” study, which showed, through an elaborate ruse, that participants were more likely to develop an attraction for someone they encountered in a dangerous setting, like a spindly bridge swaying above the rapids, than in a more staid environment. The student thought to recreate the study with the object of his affection, on a thrill ride on a rickshaw through Delhi. But it backfired: the woman fell for the rickshaw driver.

Dr. Iyengar can trace her interest in choice back to her own family life — “my first study,” as she calls it. She was raised in the collision of two cultures, each of which is based on markedly different ideas about choice. There was the strict Sikh world she was born into, “which had all sorts of rules and duties you had to think about constantly: you couldn’t cut your hair, you couldn’t talk to boys,” she said, and the American one outside her door in Flushing, Queens, for which choice, of course, is its own religion.

Further, she and her only sister were born with retinitis pigmentosa, a disease of retinal degeneration, which left both blind by the time they were in high school. Biology and culture had seemingly boxed her into a world of little choice. Was she trapped by fate or made resilient by these preconditions, she asks in her book. Certainly she was inspired by them.

As an undergraduate at the University of Pennsylvania, Dr. Iyengar looked at how religious conviction affects people’s sense of well-being. Her results were counterintuitive: the more orthodox and fundamentalist among her study group appeared to be more optimistic and resilient than the people who followed a looser, more liberal religion. Any upbeat narrative, it seems — God is in control, Coke is refreshing — helps us feel better about our choices even as it limits them. (Studies have shown that Coke’s narrative, for example, is stronger than Pepsi’s, largely owing to feelings about the color red and the soft drink’s iconic typeface, which gives Coke market share but is also the reason most folks can’t tell the difference in blind taste tests.)

Which brings us back to decorating. “One of the things we’re struggling with is what impression we want to communicate,” she said. “Do we want a warm house, do we want to come across as chic? What do those words mean? It took me a while to figure out I wanted a mix-and-match approach: I wanted a home that wasn’t purely Indian or purely American, and I wanted it to be eclectic. But what does eclectic look like?”

Dr. Iyengar knew from her research and that of others that it’s easier to choose from options sorted into categories. Coffee drinkers, for example, enjoy their coffee selection more if they choose coffee flavors from menus organized into categories like “spicy” or “nutty” than if they pick from an uncategorized list of 50 flavors.

So she and her husband visited small furniture stores, researching the feeling and look of labels like “modern,” “Colonial” and “English antique.” “The worst thing you can do first is go to a huge department store,” she said. “Once you learn what you like and realize you can’t afford any of it, then you can take that information, the shapes that appeal and the patterns they fit into, and go back into the bigger pool of choices.”

Once she made her furniture choices, every object — the dainty English desk in her bedroom, the suite of Louis chairs in the living room — was previewed by her committee. “What’s great about getting other people’s comments is you learn the problems,” she said. “You can get so enamored of something you don’t give enough weight to its drawbacks. You have to invite criticism.”

Did she have to train her gang? “At first people are nervous,” she said. “Then they loosen up, and knowing their opinions are just one of a group’s and that I don’t always go with their opinions, they get more competitive, which makes them state things in a more pure way.” It’s been a two-year process, “and we’re still not done,” Dr. Iyengar said. “You have to be choosy about what you choose.” Recently, her husband mentioned he had a hankering for a weekend house. Her response was instant, she said. “I told him he was crazy.”

Monday, 29 March 2010

Good start to 2010

By Sharon Siddique
MDS President


On Saturday afternoon, March 27, 2010, about 50 MDS members gathered at the Auditorium at MD 11 at NUS. I think we were all pleasantly surprised at how easy the venue was to locate – a short walk from the main entrance to NUH.


Our first event of 2010 was a great success! Associate Professor Caroline Chee, Senior Consultant Ophthalmologist and Head of the Vitreoretinal Service at NUH, spoke on “Advances in the Treatment of Macular Degeneration”.


Prof Chee began her lecture by zeroing in on the retina. She then gave a very clear explanation of various eye diseases involving the macula, particularly AMD and MMD. Her descriptions included the types of treatments available for various conditions, and also stages of degeneration.


Personally I found her explanation of the very important group of Anti-VEGF drugs most interesting. As a class of drugs, they are useful in stopping the growth of new blood vessels, reducing swelling, and preventing bleeding. They including Lucentis and Avastin, as well as a new (still experimental) drug called VEGF-trap. Injected directly into the eye, they are particularly effective when bleeding occurs.



The Q and A session further demonstrated what useful insights Prof Chee could share with us. Her candor and caring attitude were much appreciated by all present. We rounded out the afternoon with a tea break and networking session. And Prof Chee was the last to leave! Thanks from all of us, Prof. Chee!

Tuesday, 23 March 2010

Shuttle Bus to NUH

Members can head to NUH by taking the free NUH shuttle bus from Dover MRT station. It leaves the station every 15 minutes on Saturday.

But the last bus is at 2pm, so the shuttle will not be available for the return trip from NUH to Dover MRT station.

Thursday, 18 March 2010

Blind soldier 'sees' with his tongue

A British soldier left blind by a grenade in Iraq has told how his life has been transformed by ground-breaking technology that enables him to “see” with his tongue.


Lance Corporal Craig Lund
berg, 24, can read words, make out shapes and walk without assistance thanks to a device developed in the United States which could revolutionise life for other blind people.

Lundberg, from Liverpool in northwest England, completely lost his sight after being struck by a rocket-propelled grenade while serving in Basra in 2007. Faced with a life of relying on a guide dog, he was chosen by the Ministry of Defence as the first person in Britain to trial the BrainPort device, which could revolutionise treatment for the blind.

It converts images into electrical pulses which are sent to the tongue, where they cause a tingling sensation. The different strength of the tingles can be interpreted so the user can mentally visualise their surroundings and navigate around objects.

The device consists of a tiny video camera attached to a pair of sunglasses which are linked to a plastic “lollipop” which the user places on their tongue to read the pulses. The image is created by presenting white pixels from the camera as strong stimulation, black pixels as no stimulation, and grey levels as medium levels of stimulation, although interpreting the images takes intensive training.

“It feels like licking a nine volt battery or like popping candy,” Lundberg explained Monday. “The camera sends signals down onto the lollipop and onto your tongue. You can then determine what they mean and transfer it to shapes. “You get lines and shapes of things. It sees in black and white so you get a two-dimensional image on your tongue – it’s a bit like a pins and needles sensation.

“It’s only a prototype, but the potential to change my life is massive. It’s got a lot of potential to advance things for blind people.”

Thanks to the device, he can now “pick up objects straight away. I can reach out and pick them up when before I would be fumbling around to feel for them.” Lundberg and British military surgeons have visited the US for training in how to use the device, which is being developed by a team led by Gale Pollock, a former major general in the US army.

It is hoped that with further refinement, the BrainPort could be used for other blind British military personnel. However, the future of Lundberg’s trusty guide dog seems secure for now. “There is no way I’m getting rid of my guide dog Hugo, though – I love him. “This (the BrainPort) is another mobility device, it’s not the be-all and end-all of my disability.”- AFP

Saturday, 6 March 2010

Talk on MD treatments

Title : Advances in the Treatment of Macular Degeneration

Speaker: Associate Professor Caroline Chee, Senior Consultant Ophthalmologist.
Head of the Vitreoretinal Service, NUH

Location: Auditorium, Clinical Research Centre (CRC)
Level 1, Blk MD11, 10 Medical Drive
National University of Singapore
(Next to National University Hospital)

Date: March 27 (Sat), 2010
Time: 2 to 4pm

To register for the talk, call Anne at 6238-7387 or e-mail Sharon at alleyes@singnet.com.sg

Tuesday, 9 February 2010

Spice and saffron good for AMD?

Clinical trials in Italy and Australia have shown that the spice, saffron, can improve vision in people with AMD.The trial was conducted at Policlinico Gemelli in Italy by Professor Benedetto Falsini.

It was double blind and randomly controlled, involving 25 subjects over six months. Half the group was given a saffron pill for the first three months followed by a placebo the second three months.
The other half of the group followed the same protocol in reverse. All subjects in the first group experienced up to 2 lines of improvement in their vision while taking saffron pill, but the effect quickly disappeared when the dose was discontinued.
Researchers theorize that the improvement is a result of the anti-apoptotic properties of the spice. A 12-month dose-escalation trial is now underway at the Catholic University of Rome and the University of L'Aquila.
According to Richard Trevino, O.D., in a recent message to MDList, "It seems the research focused on improvements in vision function, rather than actual morphologic retinal improvements (eg OCT changes). This is similar to the research on lutein - it may improve the vision function of surviving cells but does not roll-back the damage that is already present.
"I have read," continued Dr. Trevino, "that the healing benefits of saffron are attributed to crocin, a carotenoid. So, rather than look for saffron pills, you may want to look for a crocin supplement, or just get more saffron in your diet."

Source: www.medindia.net

Monday, 1 February 2010

New Gene Delivery Tool

Researchers have developed a new tool for gene therapy that significantly increases gene delivery to cells in the retina compared to other carriers and DNA alone. The study was published in the January 2010 issue of The Journal of Gene Medicine by Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts (Rajendra Kumar-Singh, PhD, senior author).

A peptide called PEG-POD provides a safe and effective vehicle for transferring DNA into cells without using a virus, currently the most common means of DNA delivery. According to Dr. Kumar-Singh, PEG-POD protects DNA from damage in the bloodstream, allowing for gene therapy treatments that can be administered through an IV and directed to many other parts of the body.

The researchers used an in vivo model to compare the effectiveness of PEG-POD with two other carriers (PEG-TAT and PEG-CK30) and a control (injections of DNA alone). They found that gene expression in specimens injected with PEG-POD was far more effective than the other two carriers at 215 times greater than the control.